Bioreactor is an engineered or manufactured vessel that is used in the production of a wide range of biological products. Industrial bioreactor is a vessel in which biochemical process is being carried out using microbes and animal cells or biologically active compounds. Bioreactors are cylindrical in shape and have the most important components involved in bioprocessing. Fermentation processes are carried out in bioreactors.
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Bioreactors for large scale production of therapeutic products are made of stainless steel. In biopharmaceutical companies, small glass bioreactors are used for research and development purposes and for scale up activities. Another type of bioreactors are disposable bioreactors, which are meant for single use and hence are single-use bioreactors. It is generally used for extensive research and manufacturing. Bioreactors can be operated in batch, fed batch, and continuous stirred tank processes. Bioreactors are used to produce therapeutics, which include monoclonal antibodies, vaccines, stem cells, and gene modified cells.
The efficiency of single-use bioreactors has increased across pharmaceutical industries in terms of production, quality control, and procurement. Single-use bioreactors offer advantages such as consistency in production, increase in speed of manufacturing, reduced operational cost, and reduction in manufacturing time of finished dosage form, which foster growth of bioreactors market. In 2016, as per the National Center for Biotechnology Information (NCBI), the operational cost per gram of monoclonal antibody production (mAb) for single-use bioreactor is around 22% lower than conventional system, mainly due to less lab, utilities, maintenance, and waste.
Key vendors:
Thermo Fisher Scientific, Inc., Merck KGaA, GE Healthcare, Pall Corporation, ZETA Holdings GmbH, Sartorius AG BBI, Solaris, Praj HiPurity Systems Limited, BiOENGiNEERiNG, INC., Infors AG, and Appplikon Biotechnology, Inc.
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